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Proper Storage and Handling Guidelines Correct storage helps maintain product quality and stability

The formulation and excipients in B12 supplements often play a significant role

For doses under 20 units, a 0.3 mL or 0.5 mL syringe with 1-unit markings gives better precision than a 1 mL syringe marked in 2-unit steps

The following criteria were considered: Full economic evaluations: cost-utility analysis, cost-effectiveness analysis, cost-benefit analysis Economic evaluations reporting incremental cost-effectiveness ratios (i.e., cost per quality-adjusted life year/life years gained or cost per event avoided) Studies in patients with confirmed vitamin B12 deficiency Studies in English Abstracts were reviewed by a single reviewer and, for those studies meeting the eligibility criteria, full-text articles were obtained